The majority of affected women, according to the authors of this article, can be best served by their primary care physicians, who can then make an educated decision about whether or not to refer them to specialists. This is true even though the majority of children with Turner's syndrome are treated by specialists. This article examines current theories about Turner's syndrome genetics, diagnosis, and treatment. One of the most prevalent forms of aneuploidy in humans,Turner Syndrome (TS), affects 1 in 2 000 newborns with a female phenotype. Cytogenetically, sex chromosomal monosomy (45, X), which is present in 50%–60% of patients, is what distinguishes the syndrome. In the other circumstances, a 45, X cell line is accompanied by one or more other cell lines that have an X or Y chromosome that is complete or architecturally aberrant. The risk of gonadal malignancies, particularly gonadoblastoma, is increased in individuals with dysgenetic gonads due to the presence of Y- chromosome material. If chromosome Y-specific sequences are present, the main worry is the high chance of developing gonadoblastoma or other cancers as well as virilization after puberty
