Cancer has become a public health problem worldwide. The difficulty to develop a general approach for the disease relies on the heterogeneity of the underlying factors and the different nature of the cancer types. The use of nanodevices and nanosystems as efficient therapies for chronic-degenerative conditions (such as cancer) have shown excellent results in terms of early diagnosis and drug delivery. Through the sol-gel method, we have synthesized nanostructured metallic oxide particles impregnated with transition metals. The characterization techniques carried out (electronic microscopies, spectroscopies, surface area measurements, and catalytic assays) proved that the nanoparticles exhibit catalytic properties due to their carefully designed physicochemical characteristics: high surface area (640 m2/g), stability, selectivity, ordered mesoporous nanostructure, and nanoscopic size. The nanoparticles are functionalized with organic compounds present in cells, which allow them to be biocompatible. Their particle size (<10 nm) and the selective receptor ligands make them suitable to traverse the cytoplasmatic membrane via endocytosis to reach the subcellular structures where they carry out catalytic reactions breaking the carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds present in the DNA, hence destabilizing the molecule and activating the apoptosis mechanism that concludes in the death of the cell. The bionanocatalyzer has shown high selectivity for cancer cells with no affection to normal cells. The compound was tested with different cancer types: cervical cancer in HeLa cellular line, glioblastoma multiforme in rats, and prostate cancer in a patient. In all the studies, the bionanocatalyzer reduced tumor growth, and no toxicity nor adverse effects were observed. processing when NV fluorescence was observed. Figure 1 shows an array of sites alongside a histogram of their autocorrelation functions; 24 of the sites contain single NV centres, representing a yield of 96%. The positions of the NVs were measured by recording fluorescence imagesand fitting analytic functions. Figure 2 shows the results revealing scatter of ~40 nm laterally and 200 nm axially, about a factor of five better than with a thermal anneal. The use of a pulsed laser to perform local annealing is the key to deterministic writing as it allows site-specific control over the process.
